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Article

Genetics of early-onset Parkinson's disease in Finland: exome sequencing and genome-wide association study.

Neurobiology of aging - 1 May 2017

Siitonen Ari, Nalls Michael A, Hernández Dena, Gibbs J Raphael, Ding Jinhui, Ylikotila Pauli, Edsall Connor, Singleton Andrew, Majamaa Kari

Abstract excerpt

Several genes and risk factors are associated with Parkinson's disease (PD). Although many of the genetic markers belong to a common pathway, a unifying pathogenetic mechanism is yet to be found. Also, missing heritability analyses have estimated that only part of the genetic influence contributing to PD has been found. Here, we carried out whole-exome sequencing (WES) on 438 Finnish patients with early-onset PD....

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Source

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Identifiers

PMID: 28256260
DOI: 10.1016/j.neurobiolaging.2017.01.019
PMCID: PMC5385296

Genes

MPHOSPH10
SERPINA1
CEL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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