Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Organ-specific disease provoked by systemic autoimmunity.

Cell - 29 Nov 1996

Kouskoff V, Korganow A S, Duchatelle V, Degott C, Benoist C, Mathis D

Abstract excerpt

Rheumatoid arthritis (RA) is a chronic joint disease characterized by leukocyte invasion and synoviocyte activation followed by cartilage and bone destruction. Its etiology and pathogenesis are poorly understood. We describe a spontaneous mouse model of this syndrome, generated fortuitously by crossing a T cell receptor (TCR) transgenic line with the NOD strain. All offspring develop a joint disease highly...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to B-Lymphocytes
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to Mice, Inbred BALB C

Share to Mice, Transgenic

Share to Phenotype

Source

Identifiers

PMID: 8945509
DOI: 10.1016/s0092-8674(00)81989-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Organ-specific disease provoked by systemic autoimmunity.PMID 8945509Read ↗

Autoimmunity: Another pathway towards arthritis.Semantic proximity Read ↗

Autoimmunity versus tolerance: analysis using transgenic mice.Semantic proximity Read ↗

Autoantigens in systemic autoimmunity: critical partner in pathogenesis.Semantic proximity Read ↗

Susceptibility to systemic autoimmunity rather than the presence of the HLA-DR4 peptide binding domain alone leads to severe inflammatory arthritis following inhalation of crystalline silica.Semantic proximity Read ↗

Effector T cells in rheumatoid arthritis: Lessons from animal modelsSemantic proximity Read ↗

Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges.Semantic proximity Read ↗

The thymus and rheumatology: should we care?Semantic proximity Read ↗

Genomic view of systemic autoimmunity in MRLlpr miceSemantic proximity Read ↗

Pre-symptomatic autoimmunity in rheumatoid arthritis: when does the disease start?Semantic proximity Read ↗

Silica-mediated exacerbation of inflammatory arthritis: A novel murine modelSemantic proximity Read ↗

Targeting rheumatoid inflammation and joint destruction in the mouse.Semantic proximity Read ↗

Role of autoreactive CD8+ T cells in organ-specific autoimmune diseases: insight from transgenic mouse models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.