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Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis

5 Oct 2022

Abstract excerpt

Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic inflammation. Immune dysfunction is an essential mechanism in the pathogenesis of RA and directly linked to synovial inflammation and cartilage/bone destruction. Intermediate conductance Ca 2+ -activated K + channel (KCa3.1) is considered a significant regulator of proliferation, differentiation, and migration of immune cells by...

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PMID: 36275686
DOI: 10.3389/fimmu.2022.997621

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