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Article

Physical exercise rescues defective neural stem cells and neurogenesis in the adult subventricular zone of Btg1 knockout mice.

Brain structure & function - 1 Aug 2017

Mastrorilli Valentina, Scopa Chiara, Saraulli Daniele, Costanzi Marco, Scardigli Raffaella, Rouault Jean-Pierre, Farioli-Vecchioli Stefano, Tirone Felice

Abstract excerpt

Adult neurogenesis occurs throughout life in the dentate gyrus (DG) and the subventricular zone (SVZ), where glia-like stem cells generate new neurons. Voluntary running is a powerful neurogenic stimulus triggering the proliferation of progenitor cells in the DG but, apparently, not in the SVZ. The antiproliferative gene Btg1 maintains the quiescence of DG and SVZ stem cells. Its ablation causes intense...

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Identifiers

PMID: 28247022
DOI: 10.1007/s00429-017-1376-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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