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Article

NOTCH1 Mutations in Aortic Stenosis: Association with Osteoprotegerin/RANK/RANKL.

BioMed research international - 1 Jan 2017

Irtyuga Olga, Malashicheva Anna, Zhiduleva Ekaterina, Freylikhman Olga, Rotar Oxana, Bäck Magnus, Tarnovskaya Svetlana, Kostareva Anna, Moiseeva Olga

Abstract excerpt

Background. The NOTCH pathway is known to be important in the pathogenesis of calcific aortic valve disease, possibly through regulators of osteoprotegerin (OPG), receptor activator of nuclear factor κB (RANK), and its ligand (RANKL) system. The purpose of the present study was to search for possible associations between NOTCH1 gene mutations and circulating levels of OPG and soluble RANKL (sRANKL) in patients...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 28246602
DOI: 10.1155/2017/6917907
PMCID: PMC5299165

Genes

NOTCH1
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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