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Understanding Rifampicin Resistance in Tuberculosis through a Computational Approach

1 Jan 2014

Abstract excerpt

The disease tuberculosis, caused by Mycobacterium tuberculosis (MTB), remains a major cause of morbidity and mortality in developing countries. The evolution of drug-resistant tuberculosis causes a foremost threat to global health. Most drug-resistant MTB clinical strains are showing resistance to isoniazid and rifampicin (RIF), the frontline anti-tuberculosis drugs. Mutation in rpoB, the beta subunit of...

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PMID: 25705170
DOI: 10.5808/gi.2014.12.4.276

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