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High frequency of silent mutations in gyrA gene of Mycobacterium tuberculosis in Indian isolates.

Environmental and molecular mutagenesis - 1 Oct 2024

Gupta Anamika, Pal Sudhir K, Nema Vijay

Abstract excerpt

Reporting any uncommon or untapped changes in bacterial genetics or physiology would be of great importance to support the drug development process. We studied 120 Mycobacterium tuberculosis clinical isolates with different geographical origin within India and their resistance profile and found a significant number of isolates (109) harboring the polymorphism at nucleotide positions 61 and 284 of the gyrA gene....

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PMID: 39262280
DOI: 10.1002/em.22629

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