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Integrative multi-omics analysis revealed SNP-lncRNA-mRNA (SLM) networks in human peripheral blood mononuclear cells.

Human genetics - 1 Apr 2017

Xia Wei, Zhu Xiao-Wei, Mo Xin-Bo, Wu Long-Fei, Wu Jian, Guo Yu-Fan, Zeng Ke-Qin, Wang Ming-Jun, Lin Xiang, Qiu Ying-Hua, Wang Lan, He Pei, Xie Fang-Fei, Bing Peng-Fei, Lu Xin, Liu Yao-Zhong, Yi Neng-Jun, Deng Fei-Yan, Lei Shu-Feng

Abstract excerpt

Long non-coding RNAs (lncRNAs) serve as important controller of cellular functions via regulating RNA transcription, degradation and translation. However, what are the regulation patterns of lncRNAs on downstream mRNA and how the upstream genetic variants regulate lncRNAs are largely unknown. We first performed a comprehensive expression quantitative trait locus (eQTL) analysis (MatrixeQTL package, R) using...

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PMID: 28243742
DOI: 10.1007/s00439-017-1771-1

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