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Article

In vivo imaging of translocator protein, a marker of activated microglia, in alcohol dependence.

Molecular psychiatry - 1 Dec 2017

Hillmer A T, Sandiego C M, Hannestad J, Angarita G A, Kumar A, McGovern E M, Huang Y, O'Connor K C, Carson R E, O'Malley S S, Cosgrove K P

Abstract excerpt

Neuroinflammation may be a critical component of the neurobiology of alcohol use disorders, yet the exact nature of this relationship is not well understood. This work compared the brain and peripheral immune profile of alcohol-dependent subjects and controls. Brain levels of 18-kDa translocator protein (TSPO), a marker of microglial activation and neuroinflammation, were measured with [11C]PBR28 positron...

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Identifiers

PMID: 28242869
DOI: 10.1038/mp.2017.10
PMCID: PMC5573660

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TSPO

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