Article
N-cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage-Specific.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2017
Fontana Francesca, Hickman-Brecks Cynthia L, Salazar Valerie S, Revollo Leila, Abou-Ezzi Grazia, Grimston Susan K, Jeong Sung Yeop, Watkins Marcus, Fortunato Manuela, Alippe Yael, Link Daniel C, Mbalaviele Gabriel, Civitelli Roberto
Abstract excerpt
N-cadherin inhibits osteogenic cell differentiation and canonical Wnt/β-catenin signaling in vitro. However, in vivo both conditional Cdh2 ablation and overexpression in osteoblasts lead to low bone mass. We tested the hypothesis that N-cadherin has different effects on osteolineage cells depending upon their differentiation stage. Embryonic conditional osteolineage Cdh2 deletion in mice results in defective...
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