Article
Chondromodulin I is a bone remodeling factor.
Molecular and cellular biology - 1 Jan 2003
Nakamichi Yuko, Shukunami Chisa, Yamada Takashi, Aihara Ken-ichi, Kawano Hirotaka, Sato Takashi, Nishizaki Yuriko, Yamamoto Yoko, Shindo Masayo, Yoshimura Kimihiro, Nakamura Takashi, Takahashi Naoyuki, Kawaguchi Hiroshi, Hiraki Yuji, Kato Shigeaki
Abstract excerpt
Chondromodulin I (ChM-I) was supposed from its limited expression in cartilage and its functions in cultured chondrocytes as a major regulator in cartilage development. Here, we generated mice deficient in ChM-I by targeted disruption of the ChM-I gene. No overt abnormality was detected in endochondral bone formation during embryogenesis and cartilage development during growth stages of ChM-I(-/-) mice. However,...
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