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Article

Pneumococcal galactose catabolism is controlled by multiple regulators acting on pyruvate formate lyase.

Scientific reports - 27 Feb 2017

Al-Bayati Firas A Y, Kahya Hasan F H, Damianou Andreas, Shafeeq Sulman, Kuipers Oscar P, Andrew Peter W, Yesilkaya Hasan

Abstract excerpt

Catabolism of galactose by Streptococcus pneumoniae alters the microbe's metabolism from homolactic to mixed acid fermentation, and this shift is linked to the microbe's virulence. However, the genetic basis of this switch is unknown. Pyruvate formate lyase (PFL) is a crucial enzyme for mixed acid fermentation. Functional PFL requires the activities of two enzymes: pyruvate formate lyase activating enzyme (coded...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28240278
DOI: 10.1038/srep43587
PMCID: PMC5327383

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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