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Placental Mitochondrial Toxicity, Oxidative Stress, Apoptosis, and Adverse Perinatal Outcomes in HIV Pregnancies Under Antiretroviral Treatment Containing Zidovudine

24 Feb 2017

Abstract excerpt

OBJECTIVE: To determine whether mitochondrial, oxidative, and apoptotic abnormalities in placenta derived from HIV and combined antiretroviral therapy (cART) containing zidovudine (AZT) could be associated with adverse perinatal outcome. DESIGN: Cross-sectional, controlled, observational study. METHODS: We studied obstetric results and mitochondrial, oxidative, and apoptotic state in placenta of 24 treated...

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PMID: 28234688
DOI: 10.1097/qai.0000000000001334

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