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Article

BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells

23 Feb 2017

Abstract excerpt

Abstract Although the BCL6 transcriptional repressor is frequently expressed in human follicular lymphomas (FL), its biological role in this disease remains unknown. Herein, we comprehensively identify the set of gene promoters directly targeted by BCL6 in primary human FLs. We noted that BCL6 binds and represses NOTCH2 and NOTCH pathway genes. Moreover, BCL6 and NOTCH2 pathway gene expression is inversely...

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PMID: 28232365
DOI: 10.1158/2159-8290.cd-16-1189

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