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Article

MTA 1‐activated Epi‐micro RNA ‐22 regulates E‐cadherin and prostate cancer invasiveness

23 Feb 2017

Abstract excerpt

We have previously shown that metastasis-associated protein 1 (MTA1), a chromatin remodeler, plays an important role in prostate cancer invasiveness, likely through regulation of epithelial-to-mesenchymal transition. Here, we identified miR-22 as an epigenetic-microRNA (Epi-miR) directly induced by MTA1 and predicted to target E-cadherin. Loss-of-function and overexpression studies of MTA1 reinforced its...

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PMID: 28231399
DOI: 10.1002/1873-3468.12603

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