Article
Role of treatment-modifying MTHFR677C>T and 1298A>C polymorphisms in metformin-treated Puerto Rican patients with type-2 diabetes mellitus and peripheral neuropathy.
Drug metabolism and personalized therapy - 1 Mar 2017
Jiménez-Ramírez Francisco J, Castro Liza M, Ortiz Clarymar, Concepción Jennifer, Renta Jessicca Y, Morales-Borges Raúl H, Miranda-Massari Jorge R, Duconge Jorge
Abstract excerpt
BACKGROUND: The study was conducted to investigate potential association between MTHFR genotypes and diabetic peripheral neuropathy (DPN) in Puerto Ricans with type-2 diabetes mellitus (T2DM) treated with metformin. The prevalence of major MTHFR polymorphisms in this cohort was also ascertained. METHODS: DNAs from 89 metformin-treated patients with T2DM and DPN were genotyped using the PCR-based RFLP assay for...
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