Article
Methylenetetrahydrofolate reductase polymorphism 677C>T is associated with peripheral arterial disease in type 2 diabetes.
Cardiovascular diabetology - 7 Nov 2005
Pollex Rebecca L, Mamakeesick Mary, Zinman Bernard, Harris Stewart B, Hanley Anthony J G, Hegele Robert A
Abstract excerpt
BACKGROUND: Individuals with diabetes are twice as likely to develop peripheral arterial disease (PAD), the manifestation of extensive atherosclerosis throughout the lower extremities. One putative determinant of PAD is the 677C>T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR), which has previously been found to associate with various diabetic complications including retinopathy,...
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