Article
A mutant of the major apple allergen, Mal d 1, demonstrating hypo-allergenicity in the target organ by double-blind placebo-controlled food challenge.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Dec 2005
Bolhaar S T H P, Zuidmeer L, Ma Y, Ferreira F, Bruijnzeel-Koomen C A F M, Hoffmann-Sommergruber K, van Ree R, Knulst A C
Abstract excerpt
BACKGROUND: Allergen-specific immunotherapy for food allergy has been hindered by severe side-effects in the past. Well-characterized hypo-allergenic recombinant food allergens potentially offer a safe solution. OBJECTIVE: To demonstrate hypo-allergenicity of a mutated major food allergen from apple, Mal d 1, in vitro and in vivo. METHODS: A mutant of the major apple allergen, Mal d 1, was obtained by...
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