Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients.

doi:10.1111/apm.12659

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Article

Association of the IL-10 receptor A536G (S138G) loss-of-function variant with multiple sclerosis in Tunisian patients.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica - 1 May 2017

Ben Fredj Nadia, Aissi Mouna, Ben Selma Walid, Mahmoud Imen, Nefzi Faten, Frih-Ayed Mahbouba, Boukadida Jalel, Aouni Mahjoub

Abstract excerpt

Interleukin-10 (IL-10), a potent anti-inflammatory T-cell cytokine, has been shown to be a regulatory cytokine that is associated with disease remission in multiple sclerosis (MS) and exerts its activity through its cognate cell surface receptor complex, IL-10 receptor 1 (IL-10R1) and IL-10R2. The purpose of this study was to investigate the IL-10R1 S138G loss-of-function polymorphism (A536G: rs3135932) for...

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PMID: 28225209
DOI: 10.1111/apm.12659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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