IL-10R1 S138G loss-of-function polymorphism is associated with extrapulmonary tuberculosis risk development in Tunisia.

doi:10.1007/s11033-011-0709-2

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Article

IL-10R1 S138G loss-of-function polymorphism is associated with extrapulmonary tuberculosis risk development in Tunisia.

Molecular biology reports - 1 Jan 2012

Ben-Selma Walid, Ben-Abderrahmen Yosra, Boukadida Jalel, Harizi Hedi

Abstract excerpt

There is considerable evidence that host genetic factors are important in determining susceptibility to mycobacterial infections. More recently, functional genetic mutations affecting IL-10 receptor 1 (IL-10R1) were described. In this study, we investigated the relationship of IL-10R1 S138G loss-of-function polymorphism (A536G: rs3135932) with susceptibility to active tuberculosis (TB) in Tunisian patients. A...

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PMID: 21553229
DOI: 10.1007/s11033-011-0709-2

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