Article
Epidemiological and ES cell-based functional evaluation of BRCA2 variants identified in families with breast cancer.
Human mutation - 1 Feb 2021
Sullivan Teresa, Thirthagiri Eswary, Chong Chan-Eng, Stauffer Stacey, Reid Susan, Southon Eileen, Hassan Tiara, Ravichandran Aravind, Wijaya Eldarina, Lim Joanna, Taib Nur Aishah Mohd, Fadzli Farhana, Yip Cheng Har, Hartman Mikael, Li Jingmei, van Dam Rob M, North Susan L, Das Ranabir, Easton Douglas F, Biswas Kajal, Teo Soo-Hwang, Sharan Shyam K
Abstract excerpt
The discovery of high-risk breast cancer susceptibility genes, such as Breast cancer associated gene 1 (BRCA1) and Breast cancer associated gene 2 (BRCA2) has led to accurate identification of individuals for risk management and targeted therapy. The rapid decline in sequencing costs has tremendously increased the number of individuals who are undergoing genetic testing world-wide. However, given the significant...
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