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The p53 isoform delta133p53ß regulates cancer cell apoptosis in a RhoB-dependent manner

17 Feb 2017

Abstract excerpt

The TP53 gene plays essential roles in cancer. Conventionally, wild type (WT) p53 is thought to prevent cancer development and metastasis formation, while mutant p53 has transforming abilities. However, clinical studies failed to establish p53 mutation status as an unequivocal predictive or prognostic factor of cancer progression. The recent discovery of p53 isoforms that can differentially regulate cell cycle...

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PMID: 28212429
DOI: 10.1371/journal.pone.0172125

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