Article
Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model.
Small (Weinheim an der Bergstrasse, Germany) - 1 Apr 2017
Ribas João, Zhang Yu Shrike, Pitrez Patrícia R, Leijten Jeroen, Miscuglio Mario, Rouwkema Jeroen, Dokmeci Mehmet Remzi, Nissan Xavier, Ferreira Lino, Khademhosseini Ali
Abstract excerpt
Organ-on-a-chip platforms seek to recapitulate the complex microenvironment of human organs using miniaturized microfluidic devices. Besides modeling healthy organs, these devices have been used to model diseases, yielding new insights into pathophysiology. Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease showing accelerated vascular aging, leading to the death of patients due to...
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