Article
Motor phenotype is not associated with vascular dysfunction in symptomatic Huntington's disease transgenic R6/2 (160 CAG) mice.
Scientific reports - 17 Feb 2017
Di Pardo A, Carrizzo A, Damato A, Castaldo S, Amico E, Capocci L, Ambrosio M, Pompeo F, De Sanctis C, Spinelli C C, Puca A A, Remondelli P, Maglione V, Vecchione C
Abstract excerpt
Whereas Huntington's disease (HD) is unequivocally a neurological disorder, a critical mass of emerging studies highlights the occurrence of peripheral pathology like cardiovascular defects in both animal models and humans. The overt impairment in cardiac function is normally expected to be associated with peripheral vascular dysfunction, however whether this assumption is reasonable or not in HD is still...
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