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Article

Distinct Interactions of EBP1 Isoforms with FBXW7 Elicits Different Functions in Cancer.

Cancer research - 15 Apr 2017

Wang Yuli, Zhang Pengju, Wang Yunshan, Zhan Panpan, Liu Chunyan, Mao Jian-Hua, Wei Guangwei

Abstract excerpt

The ErbB3 receptor-binding protein EBP1 encodes two alternatively spliced isoforms P48 and P42. While there is evidence of differential roles for these isoforms in tumorigenesis, little is known about their underlying mechanisms. Here, we demonstrate that EBP1 isoforms interact with the SCF-type ubiquitin ligase FBXW7 in distinct ways to exert opposing roles in tumorigenesis. EBP1 P48 bound to the WD domain of...

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Identifiers

PMID: 28209614
DOI: 10.1158/0008-5472.CAN-16-2246
PMCID: PMC5392370

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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