Article
Probabilistic natural mapping of gene-level tests for genome-wide association studies.
Briefings in bioinformatics - 20 Jul 2018
Bao Feng, Deng Yue, Du Mulong, Ren Zhiquan, Zhang Qingzhao, Zhao Yanyu, Suo Jinli, Zhang Zhengdong, Wang Meilin, Dai Qionghai
Abstract excerpt
Genome-wide association studies (GWASs) generally focus on a single marker, which limits the elucidation of the genetic architecture of complex traits. Herein, we present a new computational framework, termed probabilistic natural mapping (PALM), for performing gene-level association tests. PALM robustly reveals the inherent genomic structures of genes and generates feature representations that can be seamlessly...
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