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Article

Transposon-mediated directed mutation in bacteria and eukaryotes.

Frontiers in bioscience (Landmark edition) - 1 Mar 2017

Saier Milton H, Kukita Chika, Zhang Zhongge

Abstract excerpt

Transposon-mediated "directed" mutations occur at higher frequencies when beneficial than when detrimental and relieve the stress that causes them. The first and best-studied example involves regulation of Insertion Sequence-5 (IS5) insertion into a specific activating site upstream of the glycerol utilization operon in Escherichia coli, glpFK. This event promotes high level expression of the glpFK operon,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28199212
DOI: 10.2741/4553
PMCID: PMC5820026

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PTS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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