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Article

Molecular dynamics of mesophilic-like mutants of a cold-adapted enzyme: insights into distal effects induced by the mutations.

PloS one - 1 Jan 2011

Papaleo Elena, Pasi Marco, Tiberti Matteo, De Gioia Luca

Abstract excerpt

Networks and clusters of intramolecular interactions, as well as their "communication" across the three-dimensional architecture have a prominent role in determining protein stability and function. Special attention has been dedicated to their role in thermal adaptation. In the present contribution, seven previously experimentally characterized mutants of a cold-adapted α-amylase, featuring mesophilic-like...

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Identifiers

PMID: 21915299
DOI: 10.1371/journal.pone.0024214
PMCID: PMC3168468

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Source receipt: pubmed, retrieved 7 Sept 2026.

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