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Article

The Effect of Gene Variants on Levonorgestrel Pharmacokinetics When Combined With Antiretroviral Therapy Containing Efavirenz or Nevirapine.

Clinical pharmacology and therapeutics - 1 Sept 2017

Neary M, Lamorde M, Olagunju A, Darin K M, Merry C, Byakika-Kibwika P, Back D J, Siccardi M, Owen A, Scarsi K K

Abstract excerpt

Reduced levonorgestrel concentrations from the levonorgestrel contraceptive implant was previously seen when given concomitantly with efavirenz. We sought to assess whether single nucleotide polymorphisms (SNPs) in genes involved in efavirenz and nevirapine metabolism were linked to these changes in levonorgestrel concentration. SNPs in CYP2B6, CYP2A6, NR1I2, and NR1I3 were analyzed. Associations of participant...

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Identifiers

PMID: 28187506
DOI: 10.1002/cpt.667
PMCID: PMC5546927

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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