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Article

OncoSimulR: genetic simulation with arbitrary epistasis and mutator genes in asexual populations.

Bioinformatics (Oxford, England) - 15 Jun 2017

Diaz-Uriarte Ramon

Abstract excerpt

SUMMARY: OncoSimulR implements forward-time genetic simulations of biallelic loci in asexual populations with special focus on cancer progression. Fitness can be defined as an arbitrary function of genetic interactions between multiple genes or modules of genes, including epistasis, restrictions in the order of accumulation of mutations, and order effects. Mutation rates can differ among genes, and can be...

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Identifiers

PMID: 28186227
DOI: 10.1093/bioinformatics/btx077
PMCID: PMC5946943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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