Article
An empirical exploration of the (delta mu)2 genetic distance for 213 human microsatellite markers.
American journal of human genetics - 1 Oct 1999
Cooper G, Amos W, Bellamy R, Siddiqui M R, Frodsham A, Hill A V, Rubinsztein D C
Abstract excerpt
Microsatellites are now used ubiquitously as genetic markers. One important application is to the assessment of population subdivision and phylogenetic relatedness. Such applications require a method of estimation of genetic distance. Here we examine the most widely used measure of microsatellite genetic distance, Goldstein et al.'s delta-mu squared ([delta mu]2), with respect to a large data set of 213 markers...
Topics
- Africa
- Alleles
- Chromosome Mapping
- Gene Frequency
- Genetic Linkage
- Genetic Markers
- Heterozygote
- Humans
- India
- Italy
- Least-Squares Analysis
- Microsatellite Repeats
- Phylogeny
- Sample Size
- Sensitivity and Specificity