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Article

Dimerization of Human Angiogenin and of Variants Involved in Neurodegenerative Diseases.

International journal of molecular sciences - 17 Sept 2021

Fasoli Sabrina, Bettin Ilaria, Montioli Riccardo, Fagagnini Andrea, Peterle Daniele, Laurents Douglas V, Gotte Giovanni

Abstract excerpt

Human Angiogenin (hANG, or ANG, 14.1 kDa) promotes vessel formation and is also called RNase 5 because it is included in the pancreatic-type ribonuclease (pt-RNase) super-family. Although low, its ribonucleolytic activity is crucial for angiogenesis in tumor tissues but also in the physiological development of the Central Nervous System (CNS) neuronal progenitors. Nevertheless, some ANG variants are involved in...

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Identifiers

PMID: 34576228
DOI: 10.3390/ijms221810068
PMCID: PMC8468037

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