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Article

Genetic variants affecting cross-sectional lung function in adults show little or no effect on longitudinal lung function decline.

Thorax - 1 May 2017

John Catherine, Soler Artigas María, Hui Jennie, Nielsen Sune Fallgaard, Rafaels Nicholas, Paré Peter D, Hansel Nadia N, Shrine Nick, Kilty Iain, Malarstig Anders, Jelinsky Scott A, Vedel-Krogh Signe, Barnes Kathleen, Hall Ian P, Beilby John, Musk Arthur W, Nordestgaard Børge G, James Alan, Wain Louise V, Tobin Martin D

Abstract excerpt

BACKGROUND: Genome-wide association studies have identified numerous genetic regions that influence cross-sectional lung function. Longitudinal decline in lung function also includes a heritable component but the genetic determinants have yet to be defined. OBJECTIVES: We aimed to determine whether regions associated with cross-sectional lung function were also associated with longitudinal decline and to seek...

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Identifiers

PMID: 28174340
DOI: 10.1136/thoraxjnl-2016-208448
PMCID: PMC5520280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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