Article
Genetics and Genomics of Longitudinal Lung Function Patterns in Individuals with Asthma.
American journal of respiratory and critical care medicine - 15 Dec 2016
McGeachie Michael J, Yates Katherine P, Zhou Xiaobo, Guo Feng, Sternberg Alice L, Van Natta Mark L, Wise Robert A, Szefler Stanley J, Sharma Sunita, Kho Alvin T, Cho Michael H, Croteau-Chonka Damien C, Castaldi Peter J, Jain Gaurav, Sanyal Amartya, Zhan Ye, Lajoie Bryan R, Dekker Job, Stamatoyannopoulos John, Covar Ronina A, Zeiger Robert S, Adkinson N Franklin, Williams Paul V, Kelly H William, Grasemann Hartmut, Vonk Judith M, Koppelman Gerard H, Postma Dirkje S, Raby Benjamin A, Houston Isaac, Lu Quan, Fuhlbrigge Anne L, Tantisira Kelan G, Silverman Edwin K, Tonascia James, Strunk Robert C, Weiss Scott T
Abstract excerpt
RATIONALE: Patterns of longitudinal lung function growth and decline in childhood asthma have been shown to be important in determining risk for future respiratory ailments including chronic airway obstruction and chronic obstructive pulmonary disease. OBJECTIVES: To determine the genetic underpinnings of lung function patterns in subjects with childhood asthma. METHODS: We performed a genome-wide association...
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