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Article

The effective rate of influenza reassortment is limited during human infection

7 Feb 2017

Abstract excerpt

We characterise the evolutionary dynamics of influenza infection described by viral sequence data collected from two challenge studies conducted in human hosts. Viral sequence data were collected at regular intervals from infected hosts. Changes in the sequence data observed across time show that the within-host evolution of the virus was driven by the reversion of variants acquired during previous passaging of...

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PMID: 28170438
DOI: 10.1371/journal.ppat.1006203

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