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Article

Human Adipose-Derived Stem Cells Expanded Under Ambient Oxygen Concentration Accumulate Oxidative DNA Lesions and Experience Procarcinogenic DNA Replication Stress.

Stem cells translational medicine - 1 Jan 2017

Bétous Rémy, Renoud Marie-Laure, Hoede Claire, Gonzalez Ignacio, Jones Natalie, Longy Michel, Sensebé Luc, Cazaux Christophe, Hoffmann Jean-Sébastien

Abstract excerpt

Adipose-derived stem cells (ADSCs) have led to growing interest in cell-based therapy because they can be easily harvested from an abundant tissue. ADSCs must be expanded in vitro before transplantation. This essential step causes concerns about the safety of adult stem cells in terms of potential transformation. Tumorigenesis is driven in its earliest step by DNA replication stress, which is characterized by the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28170194
DOI: 10.5966/sctm.2015-0401
PMCID: PMC5442744

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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