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Article

Genomic trajectories to fluoroquinolone resistance in Francisella tularensis subsp. holarctica live vaccine strain.

International journal of antimicrobial agents - 1 Dec 2020

Sutera Vivien, Hennebique Aurélie, Lopez Fabrice, Fernandez Nicolas, Schneider Dominique, Maurin Max

Abstract excerpt

OBJECTIVES: Fluoroquinolone (FQ)-resistant mutants were previously selected from the live vaccine strain (LVS) of Francisella tularensis (F. tularensis) subsp. holarctica. This study further characterised all genetic changes that occurred in these mutants during the evolutionary trajectory toward high-level FQ resistance, and their potential impact on F. tularensis antibiotic resistance and intracellular fitness....

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Source

Identifiers

PMID: 32911069
DOI: 10.1016/j.ijantimicag.2020.106153

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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