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Article

DEK-targeting DNA aptamers as therapeutics for inflammatory arthritis

6 Feb 2017

Abstract excerpt

Novel therapeutics are required for improving the management of chronic inflammatory diseases. Aptamers are single-stranded RNA or DNA molecules that have recently shown utility in a clinical setting, as they can specifically neutralize biomedically relevant proteins, particularly cell surface and extracellular proteins. The nuclear chromatin protein DEK is a secreted chemoattractant that is abundant in the...

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Share to Advanced biosensing and bioanalysis techniques
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PMID: 28165452
DOI: 10.1038/ncomms14252

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