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Article

The transcription factor CREM drives an inflammatory phenotype of T cells in oligoarticular juvenile idiopathic arthritis.

Pediatric rheumatology online journal - 20 Jun 2018

Ohl Kim, Nickel Helge, Moncrieffe Halima, Klemm Patricia, Scheufen Anja, Föll Dirk, Wixler Viktor, Schippers Angela, Wagner Norbert, Wedderburn Lucy R, Tenbrock Klaus

Abstract excerpt

BACKGROUND: Inflammatory effector T cells trigger inflammation despite increased numbers of Treg cells in the synovial joint of patients suffering from juvenile idiopathic arthritis (JIA). The cAMP response element (CREM)α is known to play a major role in regulation of T cells in SLE, colitis, and EAE. However, its role in regulation of effector T cells within the inflammatory joint is unknown. METHODS: CREM...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29925386
DOI: 10.1186/s12969-018-0253-x
PMCID: PMC6011589

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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