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Article

Moonlighting chromatin: when DNA escapes nuclear control

8 Feb 2023

Abstract excerpt

Extracellular chromatin, for example in the form of neutrophil extracellular traps (NETs), is an important element that propels the pathological progression of a plethora of diseases. DNA drives the interferon system, serves as autoantigen, and forms the extracellular scaffold for proteins of the innate immune system. An insufficient clearance of extruded chromatin after the release of DNA from the nucleus into...

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PMID: 36755071
DOI: 10.1038/s41418-023-01124-1

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