Article
Application of circulating tumor DNA in prospective clinical oncology trials - standardization of preanalytical conditions.
Molecular oncology - 1 Mar 2017
van Dessel Lisanne F, Beije Nick, Helmijr Jean C A, Vitale Silvia R, Kraan Jaco, Look Maxime P, de Wit Ronald, Sleijfer Stefan, Jansen Maurice P H M, Martens John W M, Lolkema Martijn P
Abstract excerpt
Circulating tumor DNA (ctDNA) has emerged as a potential new biomarker with diagnostic, predictive, and prognostic applications for various solid tumor types. Before beginning large prospective clinical trials to prove the added value of utilizing ctDNA in clinical practice, it is essential to investigate the effects of various preanalytical conditions on the quality of cell-free DNA (cfDNA) in general and of...
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