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Article

The translational potential of circulating tumour DNA in oncology.

Clinical biochemistry - 1 Oct 2015

Patel K M, Tsui D W Y

Abstract excerpt

The recent understanding of tumour heterogeneity and cancer evolution in response to therapy has raised questions about the value of historical or single site biopsies for guiding treatment decisions. The ability of ctDNA analysis to reveal de novo mutations (i.e., without prior knowledge), allows monitoring of clonal heterogeneity without the need for multiple tumour biopsies. Additionally, ctDNA monitoring of...

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PMID: 25889059
DOI: 10.1016/j.clinbiochem.2015.04.005

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