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Mitochondrial ferritin protects SH-SY5Y cells against H 2 O 2 -induced oxidative stress and modulates α-synuclein expression

3 Feb 2017

Abstract excerpt

Mitochondrial ferritin (FtMt) is a type of ferritin that sequesters iron. Previous studies have shown that FtMt is expressed by dopaminergic neurons in the substantia nigra and that it may be involved in the pathology of Parkinson's disease. However, the functional roles of FtMt in dopaminergic neurons remain unclear. In this study, we investigated the function of FtMt in α-synuclein regulation and its...

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PMID: 28163159
DOI: 10.1016/j.expneurol.2017.02.001

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