Article
Autonomic cardiovascular control in methyl-CpG-binding protein 2 (Mecp2) deficient mice.
Autonomic neuroscience : basic & clinical - 30 Oct 2007
Bissonnette John M, Knopp Sharon J, Maylie James, Thong Tran
Abstract excerpt
Methyl-CpG-binding protein 2 is a transcription factor that is involved in gene silencing. It is mutated in the majority of cases of Rett syndrome. This X-linked neurodevelopmental disorder is reported to involve abnormalities in autonomic cardiovascular regulation. As an initial step in understanding the basis for these abnormalities we have characterized autonomic cardiovascular function in Mecp2 deficient...
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