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Article

MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk.

BMC cancer - 3 Feb 2017

Gansmo Liv B, Bjørnslett Merete, Halle Mari Kyllesø, Salvesen Helga B, Romundstad Pål, Hveem Kristian, Vatten Lars, Dørum Anne, Lønning Per E, Knappskog Stian

Abstract excerpt

BACKGROUND: The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with an increased risk of colon cancer. In this study we assessed the impact of MDM2 del1518 on risk of ovarian and endometrial cancer. METHODS: Here, we genotyped del1518 in two large hospital-based...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies
Share to Endometrial Neoplasms
Share to INDEL Mutation
Share to Linkage Disequilibrium
Share to Ovarian Neoplasms
Share to Polymorphism, Single Nucleotide
Share to Promoter Regions, Genetic
Share to Proto-Oncogene Proteins c-mdm2

Source

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Identifiers

PMID: 28158999
DOI: 10.1186/s12885-017-3094-y
PMCID: PMC5291962

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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MDM2 promoter polymorphism del1518 (rs3730485) and its impact on endometrial and ovarian cancer risk.PMID 28158999Read ↗

Associations between the MDM2 promoter P1 polymorphism del1518 (rs3730485) and incidence of cancer of the breast, lung, colon and prostate.Semantic proximity Read ↗

Impact of MDM2 promoter SNP55 (rs2870820) on risk of endometrial and ovarian cancer.Semantic proximity Read ↗

Association of the Del1518 Promoter (rs3730485) Polymorphism in the MDM2 Gene with Breast Cancer in a Mexican Population.Semantic proximity Read ↗

Influence of MDM2 SNP309 and SNP285 status on the risk of cancer in the breast, prostate, lung and colon.Semantic proximity Read ↗

SNP285C modulates oestrogen receptor/Sp1 binding to the MDM2 promoter and reduces the risk of endometrial but not prostatic cancer.Semantic proximity Read ↗

The MDM2 promoter SNP285C/309G haplotype diminishes Sp1 transcription factor binding and reduces risk for breast and ovarian cancer in Caucasians.Semantic proximity Read ↗

Association between SNP309 and del1518 Polymorphism in MDM2 Homologue and Esophageal Squamous Cell Carcinoma Risk in Chinese Population of Shandong Province.Semantic proximity Read ↗

MDM2 promoter SNP55 (rs2870820) affects risk of colon cancer but not breast-, lung-, or prostate cancer.Semantic proximity Read ↗

A case-control study on the SNP309T → G and 40-bp Del1518 of the MDM2 gene and a systematic review for MDM2 polymorphisms in the patients with breast cancer.Semantic proximity Read ↗

Association between a functional single nucleotide polymorphism in the MDM2 gene and sporadic endometrial cancer risk.Semantic proximity Read ↗

Effect of the MDM2 promoter polymorphisms SNP309T>G and SNP285G>C on the risk of ovarian cancer in BRCA1 mutation carriers.Semantic proximity Read ↗

Association of p73 and MDM2 polymorphisms with the risk of epithelial ovarian cancer in Chinese women.Semantic proximity Read ↗

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