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Article

Phenotypic Alterations Involved in CD8+ Treg Impairment in Systemic Sclerosis

19 Jan 2017

Abstract excerpt

Systemic sclerosis (SSc) is a connective tissue disease characterized by tissue fibrosis, vasculopathy and autoimmunity. Although the exact pathogenetic mechanisms behind SSc remain to be fully elucidated, a great deal of evidence suggests the existence of an unbalanced ratio between the effector and regulatory arms of the immune system. With regard to the Treg compartment, we observed that CD8+ Treg subsets...

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PMID: 28154567
DOI: 10.3389/fimmu.2017.00018

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