Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study.

doi:10.1097/MD.0000000000006052

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Minor variant of rs 16827043 in the iron regulator hemojuvelin gene (HJV) contributes to hypertension: The TAMRISK study.

Medicine - 1 Feb 2017

Nikkari Seppo T, Visto Anni-Laura, Määttä Kirsi M, Kunnas Tarja A

Abstract excerpt

It is known that iron overload may lead to an increased risk for many diseases. According to GWAS studies, iron regulatory protein HFE gene variant H63D (rs1799945) was associated with hypertension, an observation which we were able to confirm also in our TAMRISK cohort. Thus, it is possible that abnormalities in iron homeostasis may predispose to hypertension. This prompted us to study whether there is an...

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PMID: 28151915
DOI: 10.1097/MD.0000000000006052
PMCID: PMC5293478

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rs1799945

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