Article

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse <i>Pkd2</i> model gene expression reversion

2022-12-03

Abstract excerpt

Autosomal dominant polycystic kidney disease (ADPKD) is one of the most prevalent monogenic human diseases. It is mostly caused by pathogenic variants in PKD1 or PKD2 genes that encode interacting transmembrane proteins polycystin-1 (PC1) and polycystin-2 (PC2). Among many pathogenic processes described in ADPKD, those associated with cAMP signaling, inflammation, and metabolic reprogramming appear to regulate t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 8077b0d1-bb55-5628-bf19-7894d0352694
DOI: 10.1101/2022.12.02.518863

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Prioritized polycystic kidney disease drug targets and repurposing candidates from pre-cystic and cystic mouse <i>Pkd2</i> model gene expression reversionDOI 10.1101/2022.12.02.518863Read

Therapeutic targets for polycystic kidney disease.Semantic proximity Read

Systems biology approaches toward autosomal dominant polycystic kidney disease (ADPKD)Semantic proximity Read

Systems biology approach to identify transcriptome reprogramming and candidate microRNA targets during the progression of polycystic kidney disease.Semantic proximity Read

Meta-analysis of polycystic kidney disease expression profiles defines strong involvement of injury repair processes.Semantic proximity Read

Drug Repurposing in Rare Diseases: An Integrative Study of Drug Screening and Transcriptomic Analysis in Nephropathic CystinosisSemantic proximity Read

NS398 as a potential drug for autosomal-dominant polycystic kidney disease: Analysis using bioinformatics, and zebrafish and mouse models.Semantic proximity Read

Targeting new cellular disease pathways in autosomal dominant polycystic kidney diseaseSemantic proximity Read

Insights Into the Molecular Mechanisms of Polycystic Kidney DiseasesSemantic proximity Read

Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networksSemantic proximity Read

Polycystic kidney disease: a Hippo connection.Semantic proximity Read

The molecular landscape of polycystic kidneys is marked by common alterations in purine metabolismSemantic proximity Read

Identification of druggable targets in acute kidney injury by proteome- and transcriptome-wide Mendelian randomization and bioinformatics analysisSemantic proximity Read