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Article

Analysis and comparison of somatic mutations in paired primary and recurrent epithelial ovarian cancer samples.

PloS one - 1 Jan 2014

Kim Yong-Man, Lee Shin-Wha, Chun Sung-Min, Kim Dae-Yeon, Kim Jong-Hyeok, Kim Kyu-Rae, Kim Young-Tak, Nam Joo-Hyun, van Hummelen Paul, MacConaill Laura E, Hahn William C, Jang Se Jin

Abstract excerpt

The TP53 mutations have been proved to be predominated in ovarian cancer in a study from The Cancer Genome Atlas (TCGA). However, the molecular characteristics of recurrent ovarian cancers following initial treatment have been poorly estimated. This study was to investigate the pattern of somatic point mutations in matched paired samples of primary and recurrent epithelial ovarian cancers, using the OncoMap...

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Cyclin-Dependent Kinase Inhibitor p16
Disease-Free Survival
Kaplan-Meier Estimate
MutL Protein Homolog 1
Neoplasm Recurrence, Local

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms, Cystic, Mucinous, and Serous

Ovarian Neoplasms

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Open in PubMed Open full text

Identifiers

PMID: 24936796
DOI: 10.1371/journal.pone.0099451
PMCID: PMC4060993

Genes

KRAS
MLH1

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