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CKAP4 and mutant p53 cooperatively abrogate cell cycle checkpoint to induce genotoxic resistance in ovarian cancer

1 Nov 2023

Abstract excerpt

Dear Editor, Ovarian cancer is the most lethal gynecologic malignancy, primarily characterized by frequent mutations in the TP53 gene. While platinum-based chemotherapy has been widely utilized in the treatment of ovarian cancer, patients often experience relapse due to the development of drug resistance. Cytoskeleton-associated protein 4 (CKAP4) was found to maintain the tubular network along the endoplasmic...

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PMID: 37983936
DOI: 10.1002/ctm2.1476

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